We're currently looking for two post-doctoral researchers to join an ERC-Funded project using single-cell sequencing (RNA and ATAC) to investigate gene regulatory network evolution and cell-fate specification in sea urchins.
One the computational side, we're looking for a researcher for two sub-projects: i) The development of an allele-specific analysis pipeline to help us understand GRN evolution in hybrid sea urchin larvae and ii) An analysis of cell fate transitions during the specification of the larval skeleton.
On the wet-lab side, we're looking for a researcher with previous experience with marine embryos to look at how regulatory landscapes change in response to perturbations (e.g. transfating).
We're looking for two researchers/assistants/students on a fellowship* basis on both the wet and dry sides of the lab.
On the wetlab end of the lab, we're looking for someone to help us to extend current ATAC-Seq and RNA-Seq protocols (single-cell and bulk) to work on a range of unusual marine organisms whose cells don't hold up well in standard buffer conditions.
In the dry (computational) lab, we have two projects:
1) Characterising the onset of zygotic transcription in early sea urchin embryos using allele-specific RNA-Seq
2) Quantifying natural selection in coding and non-coding DNA associated with adaptation to deep water habitats in North American sea urchin species.
Both projects require familiarity with command-line tools and some knowledge of R or Python (ideally both).
For both the wet and dry, the projects can stand by themselves or be developed into Masters and (potentially) PhD projects.
For more information, please contact us.
*Yes, this means we pay you.
This Fall, we will enroll the first cohort of students in a graduate training program entitled 'Dissecting and Reengineering the Regulatory Genome'. Yay! The program is joint with Duke University and provides a chance to study with a range of faculty members both in Berlin and North Carolina. We'll be hiring at least one student for the urchin end of the lab. Applications are due September 15th.
IRI for the Life Sciences
Humboldt-Universität zu Berlin
Philippstr. 13 (Haus 18)